Safety and efficacy of polymyxin B in multidrug resistant gram-negative severe sepsis and septic shock
Background and Aims: The emergence of multidrug resistant strains of Gram-negative bacteria, especially the lactose nonfermenters like Pseudomonas and Acinetobacter, in the intensive care units have prompted renewed worldwide interest in the polymyxins. However, perceived nephrotoxicity has been a major vexation limiting their early and regular use in severe sepsis. This study was conducted to [...]
Tags: Acute renal failure, Gram-negative organisms, multidrug resistant, polymyxin B, severe sepsis and septic shock