Norepinephrine (NE) is mostly used to treat severe hypotension. However, NE has potentially adverse vasoconstrictive effects on regional vascular beds of kidney, liver, and gut, with a potential for ensuing organ dysfunction. NE therefore is considered as a last reserve in otherwise refractory hypotension. During sepsis, a loss of catecholamine responsiveness occurs that is often [...]
Tags: blood flow, hypotension, NE, norepinephrine, organ dysfunction, sepsis, vasoconstriction
Background: The Institute of Medicine calls for the use of
clinical guidelines and practice parameters to promote “best
practices” and to improve patient outcomes.
Objective: 2007 update of the 2002 American College of Critical
Care Medicine Clinical Guidelines for Hemodynamic Support of
Neonates and Children with Septic Shock.
Participants: Society of Critical Care Medicine members with
special interest in neonatal and pediatric [...]
Tags: guidelines, Hemodynamic Support, sepsis, severe sepsis
Objective: To provide an update to the original Surviving Sepsis Campaign
clinical management guidelines, “Surviving Sepsis Campaign Guidelines for Management
of Severe Sepsis and Septic Shock,” published in 2004.
Design: Modified Delphi method with a consensus conference of 55 international
experts, several subsequent meetings of subgroups and key individuals,
teleconferences, and electronic-based discussion among subgroups and among
the entire committee. This [...]
Tags: Assessment, Development and Evaluation criteria, evidence-based medicine, GRADE, Grades of Recommendation, guidelines, infection, sepsis, sepsis bundle, sepsis syndrome, septic shock, severe sepsis, Surviving Sepsis Campaign